If you’re exploring collagen-boosting injectables for your aesthetic practice, you’ve likely come across both Juvelook and Lenisna. We’re asked almost daily here at our academy: “Which one should I train in first?”

Overview of Both Treatments

Both Juvelook and Lenisna have become go-to treatments in 2025 for practitioners wanting to offer serious skin rejuvenation. They’re both hybrid skin boosters—meaning they combine Poly-D-Lactic Acid (PDLA) with Hyaluronic Acid (HA) to give patients instant hydration plus long-term collagen production.

But here’s where it gets interesting. Even though they share similar base ingredients, we’ve noticed completely different results when our trainees use them on live models. Understanding the difference between Juvelook and Lenisna isn’t just academic—it directly impacts which patients you’ll treat and how you’ll build your injectable portfolio.

At AM Aesthetics London, we’ve trained over 300 practitioners in both techniques this year alone, and the feedback has been fascinating.

Ingredients and Mechanism

Juvelook – The Texture Specialist

Juvelook combines Polylactic Acid (PLA) with non-crosslinked Hyaluronic Acid. Understand the formulation and science behind Juvelook’s collagen-stimulating power—what makes it unique is the particle size and how it releases, designed to stimulate fibroblasts gradually, building collagen over weeks rather than days.

In our hands-on sessions, trainees consistently report how smooth Juvelook feels under injection. The key components include PDLA, non-crosslinked HA, and sodium hyaluronate for hydration balance. It acts as a biostimulator, promoting gradual collagen synthesis while giving that immediate plumpness patients love seeing right after treatment.

We’ve found it works exceptionally well for fine lines, enlarged pores, loss of elasticity, and dull skin that’s lost its glow.

Lenisna – The Lifting Specialist

Lenisna also contains PDLA and HA, but the molecular structure is different. The particles are slightly larger and crosslinked differently, designed for deeper dermal rejuvenation and subtle volume restoration.

One trainer here describes it as “Juvelook‘s older sister”—it goes deeper and tackles more structural concerns. It includes PDLA with crosslinked Hyaluronic Acid and trehalose for antioxidant stability. This formulation focuses more on lifting and tightening by replenishing collagen in mid-to-deep dermal layers.

Our model patients often comment that Lenisna feels more “structural” during their follow-up appointments—there’s a firmness that builds over time, especially around the jawline and cheeks. It’s ideal for sagging, loss of firmness, and moderate skin laxity.

Treatment Longevity and Results

Here’s the question every trainee asks during our workshops: “Which skin booster gives longer-lasting results—Juvelook or Lenisna?”

Based on what we’ve seen across hundreds of patient cases, Lenisna tends to provide longer-lasting structural improvements. Patients often see results holding for 18-24 months, especially when they’re diligent with the full protocol. Juvelook, on the other hand, delivers that immediate radiance and texture refinement our trainees love demonstrating, with results typically lasting 12-18 months.

The depth of action differs too. Juvelook works beautifully in the superficial to mid-dermis, making it perfect for texture and glow. Lenisna reaches deeper dermal layers, which is why we see better lifting and tightening results in more mature patients.

Here’s how they compare in real-world practice: Juvelook stimulates Type I and Type III collagen, working in the superficial to mid-dermis with immediate and natural hydration. Patients usually need 2-3 monthly sessions. Lenisna focuses on Type I collagen in the mid to deep dermis, offering moderate hydration with more structure, and typically requires just 2 sessions spaced 6-8 weeks apart.

For patients seeking refined texture and glow, Juvelook stands out every time. For those needing tighter, lifted skin, Lenisna delivers results that keep patients coming back.

Ideal Candidates

Juvelook Works Best For:

We’ve noticed Juvelook performs brilliantly on younger clients aged 25-40 who are focused on preventive anti-ageing. They’re dealing with early fine lines, visible pores, and that loss of radiance that comes with stress and lifestyle factors. These patients typically want natural results and minimal downtime—something they can fit into a lunch break.

Lenisna Shines With:

Lenisna is our go-to recommendation for mature clients aged 35-55 who are experiencing actual sagging or volume loss. When we see patients concerned about jowling, softening jawlines, or loss of cheek definition, that’s when we suggest Lenisna training for practitioners. These patients want structural lifting and firmness—not just surface improvement.

Here’s something interesting we’ve learned: both treatments complement each other beautifully. Some of our most experienced graduates alternate between Juvelook and Lenisna across treatment cycles, layering the benefits for comprehensive, multi-layer rejuvenation. We cover these combination protocols in our advanced modules.

Which One Should You Train In?

At AM Aesthetics London Academy, we offer CPD-accredited Juvelook training and Lenisna training for licensed medical professionals. But which should you start with?

Juvelook Training focuses on collagen-stimulating protocols for texture refinement and glow. It’s an excellent foundation if you’re new to biostimulators because it’s forgiving and versatile.

Lenisna Training emphasizes volumetric rejuvenation, tightening, and contour restoration. We typically recommend this as your second certification once you’re comfortable with collagen-boosting injectables.

Here’s our honest comparison based on teaching both courses throughout 2025:

Juvelook Training is suited for beginner to intermediate practitioners. The focus is biostimulation and hydration, with full model practice included and CPD accreditation. We’ve found practitioners who master Juvelook first tend to have more confidence when they move into advanced techniques.

Lenisna Training is intermediate to advanced level. The focus shifts to collagen lifting and tightening, also with model practice and CPD accreditation. One common mistake we see during training is practitioners trying to use the same injection depth they learned with Juvelook—Lenisna requires a deeper, more structural approach.

Our recommendation? Start with Juvelook training if you’re new to collagen boosters. Join the AM Aesthetics London Academy’s Juvelook Training Course to master advanced collagen skin booster techniques. Its versatility makes it a perfect foundation, and you’ll build your patient base quickly with the immediate glow results. Then advance to Lenisna training once you want to tackle more complex rejuvenation cases and offer lifting treatments.

Frequently Asked Questions

What’s the main difference between Juvelook and Lenisna?

The main difference comes down to depth and goal. Juvelook targets surface texture and collagen stimulation in the upper dermal layers, giving you that glow and smoothness. Lenisna works deeper for volume and tightening, tackling structural concerns like sagging and loss of firmness. Think of Juvelook as your texture specialist and Lenisna as your lifting specialist.

Can Juvelook and Lenisna be combined?

Absolutely—and we encourage it once you’re confident with both techniques. Some of our most experienced graduates alternate between Juvelook and Lenisna across treatment cycles, layering the benefits for comprehensive rejuvenation. We cover these combination protocols in detail during our advanced skin booster comparison workshops.

How long do the results last?

From what we’ve tracked with our graduates’ patient outcomes, Juvelook results typically last 12-18 months, while Lenisna can extend to 24 months depending on patient factors like age, lifestyle, and skin quality. The longevity also depends on completing the full treatment protocol—cutting sessions short usually means shorter-lasting results.

Is training required to administer these injectables?

Yes, both require medical qualifications and certified training. You can’t just watch a YouTube video and start injecting—these are serious medical procedures. We offer full CPD-accredited courses at AM Aesthetics London Academy that cover anatomy, product knowledge, injection technique, complication management, and live model practice.

Which is better for skin tightening?

Lenisna generally provides better lifting and tightening effects because it works in those deeper dermal layers. But here’s the nuance: if your patient’s main concern is crepey texture with minimal sagging, Juvelook might actually give more satisfying results. It’s about matching the product to the patient concern, which is exactly what we teach in our Juvelook vs Lenisna training comparison sessions.

Get Certified at AM Aesthetics London Academy

Ready to add these advanced collagen boosters to your practice? We’re running hands-on training courses throughout 2025 at AM Aesthetics London Academy, with full CPD accreditation and live model practice included.

Whether you’re starting with Juvelook or advancing to Lenisna techniques, you’ll leave confident and certified. Our team is here to guide you through every injection angle, patient consultation, and complication scenario you might face in real practice.

We’ve trained everyone from GPs transitioning into aesthetics to experienced nurses expanding their injectable portfolio. Learn how mastering Juvelook can enhance your aesthetic practice and boost patient satisfaction. The feedback we hear most often? “I wish I’d done this training six months ago—my patients are thrilled with the results.”

Book your spot while model availability lasts. Our courses fill up quickly, especially during autumn and winter when practitioners are building their skills for the busier spring season.